SH3KBP1 — SH3 domain containing kinase binding protein 1
SH3KBP1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SH3KBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Immune Regulation Immune regulation | ADAT2, AFTPH, C2CD4B, CDKL2, CPEB4, DDHD1, FAM53B, FAS +10 more | View in SCUBA |
| Gamma-delta T cells | Butyrophilin gd Activation TCR Signaling | ABI1, ADD3, ANXA6, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1 +16 more | |
| Innate lymphoid cells | Actin Cytoskeletal Regulation Cytoskeleton & motility | AQP3, CCDC57, CLPTM1, COTL1, DCAF11, GSN, GYG1, MZT2B +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Integrin Actin Adhesion migration & adhesion | ACTR2, ANKRD10, ATP2B1, DDX46, HP1BP3, HPS3, JAK1, LINS1 +11 more | |
| Neutrophils | Actin Cytoskeletal Remodeling Cytoskeletal | ACAP2, ARHGAP15, COP1, CUX1, DOCK8, DPYD, KDM2A, MED13L +9 more | |
| Smooth muscle cells | Capillary Pericyte Development | ADAP2, ADRA2A, ANKRD29, CCL8, CNGA1, ENPEP, EPHA2, EPS8L1 +10 more | View in SCUBA |
About the gene
| Synonyms | CIN85 |
|---|---|
| Chromosome | X: 19533977-19887600 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Apoptosis, Endocytosis, Host-virus interaction |
Function
Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3- kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.