SERTAD2 — SERTA domain containing 2
SERTAD2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SERTAD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing Regulation RNA processing & translation | ARF6, BTG3, CAPN7, CDV3, CELF2, CNBD2, CUL3, CYTIP +18 more | |
| Lymphatic endothelial | Stress Kinase Signaling Stress | ATP13A3, CLN8, CREBRF, CYLD, DYRK3, INO80D, IPO5, KLHL21 +6 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | CCSER2, CUX1, ECPAS, EPB41L3, FUBP1, GATAD2A, GNA12, LRRFIP2 +10 more | View in SCUBA |
About the gene
| Synonyms | KIAA0127, Sei-2, TRIP-Br2 |
|---|---|
| Chromosome | 2: 64631621-64751005 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.