TAF1D — TATA-box binding protein associated factor, RNA polymerase I subunit D
TAF1D belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TAF1D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA Splicing RNA processing | AFF4, ARL6IP1, CALR, CCNL1, CLK1, DDX3X, DDX5, EIF4A2 +7 more | View in SCUBA |
| CD4⁺ T cells | RNA processing RNA processing | AARSD1, ABHD14A, AMD1, CALM2, CDKN2AIP, CHMP1B, FRAT1, HNRNPAB +7 more | View in SCUBA |
| Gamma-delta T cells | Autophagy Stress Response Stress | AKIRIN1, BRD9, CDKN2AIP, DHX36, DNAJB2, FOXO3, MLXIP, ODF2L +11 more | |
| Innate lymphoid cells | mRNA Stability & Splicing RNA processing & translation | BUD31, EIF4G2, GNAI3, HSPA9, PABPC1, PABPC4, PAIP2, PAPOLA +6 more | View in SCUBA |
| Lymphatic endothelial | Stress Kinase Signaling Stress | ATP13A3, CLN8, CREBRF, CYLD, DYRK3, INO80D, IPO5, KLHL21 +6 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L +20 more | View in SCUBA |
About the gene
| Synonyms | JOSD3, MGC5306, TAF(I)41 |
|---|---|
| Chromosome | 11: 93729948-93784391 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.