AP-1 Immediate Early
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 16 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 16 genes have a known function matching the annotation |
Why this annotation
The module is anchored by canonical immediate-early genes (IEGs): FOS, FOSB, JUN, JUNB, JUND (AP-1 family), EGR1, ZFP36 (TTP, mRNA destabilizer co-induced with AP-1), IER2 (immediate-early response), KLF4 and KLF2 (shear-stress/flow-responsive Krüppel-like factors in endothelial cells), SOCS3 (JAK-STAT feedback inhibitor, rapidly induced), HES1 (Notch target, rapidly induced), DUSP1 (MAPK phosphatase, IEG), MYC (proto-oncogene, IEG), PHLDA1 (stress/growth factor response), HSPA8 (constitutive Hsp70). KLF2 and KLF4 are particularly notable as flow-responsive transcription factors in lymphatic endothelial cells. This is a classic AP-1/IEG activation module, likely reflecting mechanosensory or cytokine stimulation responses in LECs. Neighbors M47 and M60 (stress modules) support a shared stimulus-response neighborhood.
Genes
DUSP1, EGR1, FOS, FOSB, HES1, HSPA8, IER2, JUN, JUNB, JUND, KLF2, KLF4, MYC, PHLDA1, SOCS3, ZFP36
Most correlated modules
- DNA Damage Response · correlation 0.78
- Lymphatic Valve Formation · correlation 0.77
- Integrated Stress Response · correlation 0.70
- Heat Shock Response · correlation 0.69
- Stress Granule Assembly · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.