DNA Damage Response
Gene co-expression module in Lymphatic endothelial
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include H2AX (histone variant phosphorylated at DNA double-strand breaks, canonical DNA damage marker), TOB1 (anti-proliferative, DNA damage checkpoint), BTG2 (DNA damage-inducible anti-proliferative gene), PLK2 (polo-like kinase induced by DNA damage/p53), NR4A1 and NR4A2 (nuclear receptors induced by genotoxic stress), HEXIM1 (P-TEFb inhibitor, transcriptional stress), CITED2 (CBP/p300 co-activator, stress/hypoxia), UBE2S (ubiquitin-conjugating enzyme, DNA damage repair), BRD2 (bromodomain, chromatin remodeling at DSBs), HBEGF (stress-induced growth factor), PPP1R10 (PNUTS, phosphatase regulator at DNA damage sites), INTS6 (Integrator complex, transcription-coupled repair), MAFB (stress-responsive TF). The combination of H2AX, TOB1, BTG2, PLK2, and NR4A1/2 strongly supports a DNA damage response program. Neighbor M89 (AP-1/IEG) and M47 (ISR) are consistent with a broader genotoxic/cellular stress neighborhood.
Genes
BRD2, BTG2, CITED2, H2AX, HBEGF, HEXIM1, INTS6, MAFB, NR4A1, NR4A2, PLK2, PPP1R10, TOB1, TRA2B, TUBB2A, UBE2S
Most correlated modules
- AP-1 Immediate Early · correlation 0.78
- Lymphatic Valve Formation · correlation 0.78
- Stress Granule Assembly · correlation 0.76
- Integrated Stress Response · correlation 0.69
- Heat Shock Response · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.