PPP1R15B — Protein phosphatase 1 regulatory subunit 15B

PPP1R15B belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PPP1R15B's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate Early NFkB BCR/AP1/NFKb pathway	ARL5B, CDKN1A, CSRNP1, DUSP2, EGR1, EGR3, IER2, NFKBIA +3 more	View in SCUBA
CD4⁺ T cells	NF-kB Feedback Response TCR/AP1/NFKb pathway	ADGRE5, ARL5B, ATF3, CSRNP1, NFKBIZ, RASGEF1B, TIPARP, TNFAIP3 +2 more	View in SCUBA
Fibroblasts	Proteotoxic Stress Survival Stress	ARL5B, BAG3, DNAJA4, ICAM1, PPIF, SLC25A25, TIPARP, TNFRSF10D	View in SCUBA
Gamma-delta T cells	NF-κB Activation Inflammation	DUSP5, GADD45A, HERPUD1, IL21R, KDM6B, MAFF, NAMPT, NFKB1 +13 more
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	NF-κB Inflammatory Activation Inflammation	BCL3, CD83, HIF1A, INSIG1, IPO7, IRF1, KDM6B, MAP3K8 +1 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Monocytes	AP-1 Stress Response Stress	BTG2, FOSB, MYLIP, PLK3, PMAIP1, PPP1R10, RGS2, VMP1 +1 more	View in SCUBA
Mucosal-associated invariant T cell	TCR-Induced Early Response TCR Signaling	ATF3, EGR1, GLA, HMGCS1, IER3, NR4A1, NUP58, RHOB +3 more
Natural Killer cells	Integrated Stress Response Stress	FAM43A, IER2, IER5, MARCKSL1, NFKBIA, NFKBIZ, PMAIP1, PPP1R15A +1 more	View in SCUBA

About the gene

Synonyms	FLJ14744
Chromosome	1: 204396492-204411887
Predicted location	Intracellular
Essential gene	Yes
Protein class	Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins
Biological process	Translation regulation

Function

Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.