PDGFD — Platelet derived growth factor D
PDGFD belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDGFD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV1, CAV2, CCDC85A, CD320, EEPD1, EMP2, ENAH +19 more | View in SCUBA |
| Fibroblasts | Myofibroblast Subtype Wound healing | EDNRB, FOXL1, HACD4, KCTD9, MGLL, POSTN, TSPAN33, ZEB1 | View in SCUBA |
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1 +25 more | |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | CCDC141, EFNB2, EPB41, FBXO34, FGD6, GUCY1A1, ITGA6, MDFIC +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ABTB3, AOAH, ARID1B, ARID2, ATP8A1, ATXN1, BRAF, CCSER2 +13 more |
About the gene
| Synonyms | IEGF, MSTP036, SCDGF-B |
|---|---|
| Chromosome | 11: 103907189-104164379 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Developmental protein, Growth factor, Mitogen |
Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.