SPTY2D1 — SPT2 chromatin protein domain containing 1
SPTY2D1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPTY2D1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector activation NFkB TCR/AP1/NFKb pathway | ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more | View in SCUBA |
| Gamma-delta T cells | Chromatin-Splicing Regulation DNA/chromatin regulation | ANKRD11, BOD1L1, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MED10 +13 more | |
| Innate lymphoid cells | Transcriptional Activation DNA regulation & transcription | AKIRIN1, CHORDC1, FAM133B, FAM53C, GOLGB1, GTF2B, IDI1, MORF4L2 +9 more | View in SCUBA |
| Macrophages | RNA Processing Regulation Housekeeping | ACBD3, AQR, ARCN1, BFAR, BNIP3L, CCNI, CCNK, DIS3 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | Stress Granule Response Stress | BZW1, CRTC2, EZR, G3BP2, HERPUD2, HNRNPUL1, MAP3K8, MAPK1IP1L +3 more | |
| Natural Killer cells | TGF-beta Repression DNA regulation & transcription | BZW1, GTF2B, HBP1, ODC1, POLR2K, SKIL, SKP1, UBE2D3 | View in SCUBA |
About the gene
| Synonyms | DKFZp686I068, FLJ39441, Spt2 |
|---|---|
| Chromosome | 11: 18606403-18634791 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4. Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.