PRDM2 — PR/SET domain 2
PRDM2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRDM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Modification DNA/chromatin regulation | AKAP13, CREBRF, EPC1, GCC2, GPBP1, JMJD1C, KMT2E, OFD1 +6 more | View in SCUBA |
| CD4⁺ T cells | Chromatin transcription regulation DNA/chromatin regulation | ADAM10, CIRBP, CLIP1, CUL9, GRPEL2, HBP1, KDM2A, NCOA3 +10 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C +17 more | |
| Macrophages | Epigenetic Remodeling Housekeeping | AFF4, AGO3, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, EPC1 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Maintenance Housekeeping | DCTN4, FAM13B, GBF1, GOLGA4, GPRIN3, HUWE1, ITSN2, PAFAH1B1 +4 more |
About the gene
| Synonyms | HUMHOXY1, KMT8, KMT8A, MTB-ZF, RIZ, RIZ1, RIZ2 |
|---|---|
| Chromosome | 1: 13700188-13825079 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Methyltransferase, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA- responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.