Mature Effector MAIT
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include S1PR1 (lymphoid egress receptor marking naive/central memory recirculation), KLRG1 (terminal differentiation marker), GZMK (granzyme K, effector cytotoxicity), ITGB2 (LFA-1, lymphocyte adhesion/trafficking), MYO1F (actin-based motility), CCL5 (chemokine secretion), ITGA6 (integrin homing), PLEK (pleckstrin, lymphocyte activation scaffold), and APOBEC3G (innate restriction factor). Together these define a mature, circulating, effector-competent MAIT state with tissue-egress and cytotoxic potential. Neighbor M34 shares cytoskeletal/migratory genes, supporting an effector motility neighborhood.
Genes
ADD3, ANTKMT, APOBEC3G, CCL5, CXXC5, FHL3, GZMK, ITGA6, ITGB2, KLRG1, MYO1F, PLEK, S1PR1, SAMD3, TSPAN32, TTC16
Most correlated modules
- Cytoskeletal Remodeling Migration · correlation 0.88
- Chromatin Maintenance State · correlation 0.84
- T cell Homeostasis · correlation 0.83
- Cytotoxic Lymphocyte Program · correlation 0.83
- Cytotoxic Effector · correlation 0.79
- T cell Surface Signaling · correlation 0.79
- Chromatin Complex Regulation · correlation 0.79
- Leukocyte Housekeeping · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.