RAP2B — RAP2B, member of RAS oncogene family
RAP2B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAP2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR-Cytokine Signaling TCR Signaling | ARHGAP26, CACNA2D2, CCDC88C, LPGAT1, LY75, MED15, NBPF14, NBPF19 +10 more | |
| Goblet cells | EGF-Driven Wound Repair Epithelial development | AREG, ARL14, C3orf52, CXCL8, F11R, HBEGF, NCOA7, RHPN2 +1 more | View in SCUBA |
| Macrophages | Autophagy Vesicular Trafficking Vesicular traficking | ACTR2, AHCYL1, ALKBH5, BECN1, BICD2, CAP1, CAPRIN1, COLGALT1 +32 more | View in SCUBA |
| Mucosal-associated invariant T cell | PI3K-Calcineurin Signaling TCR Signaling | ACLY, BCL9L, CABIN1, CDK11A, LATS2, NBPF19, NUP210, PIK3CD +2 more |
About the gene
| Chromosome | 3: 153162226-153170627 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.