RNF19B — Ring finger protein 19B
RNF19B belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNF19B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector activation NFkB TCR/AP1/NFKb pathway | ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more | View in SCUBA |
| Endothelial | Procoagulant TGF-β Response Inflammation | CITED4, CSF3, EHD1, F3, LAMC1, LIPG, MED24, PLEKHO1 +7 more | View in SCUBA |
| Innate lymphoid cells | NF-κB Inflammatory Activation Inflammation | AHI1, CD83, FAM107B, FKBP2, GADD45A, HES4, KDM6B, MRPS36 +7 more | View in SCUBA |
| Monocytes | TNF-driven Activation Inflammatory | ATP13A3, CD44, DCUN1D3, DSE, GK, IVNS1ABP, LAMB3, LITAF +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | Stress-Induced Growth Arrest Stress | CDKN1A, GNA15, KDM6B, KLF10, MMP9, MYADM, NOCT, NR4A3 +8 more | |
| Neutrophils | NF-κB Inflammatory Transcription Inflammatory | BID, C9orf72, DENND5A, ELL2, ETF1, N4BP1, NFE2L2, NFKB1 +10 more |
About the gene
| Synonyms | FLJ90005, IBRDC3, NKLAM |
|---|---|
| Chromosome | 1: 32936445-32964809 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Adaptive immunity, Immunity, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.