SDHD — Succinate dehydrogenase complex subunit D
SDHD belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SDHD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Homeostasis Housekeeping | ATP6V0E1, CALHM2, CNPY2, CSK, CSTB, DAD1, FERMT3, GTF2H5 +11 more | |
| Innate lymphoid cells | Antigen Processing MHC-I Immune regulation | CMTM6, GUK1, IL2RB, IL4R, MYL12A, PAXX, PSMA5, PSMB8 +8 more | View in SCUBA |
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Metabolism & Redox Mitochondrial & OxPhos | ATP5PF, CHURC1, DAD1, DHRS7, EGLN2, HMOX2, ITM2B, MRPS21 +7 more |
About the gene
| Synonyms | cybS, PGL, PGL1 |
|---|---|
| Chromosome | 11: 112086824-112120016 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Essential proteins, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Electron transport, Transport, Tricarboxylic acid cycle |
Function
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol- oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.