TNFAIP8L2 — TNF alpha induced protein 8 like 2
TNFAIP8L2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFAIP8L2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Survival T cell maturation | CASP1, CCDC107, CTU1, GEMIN7, GIMAP1, GIMAP2, GIMAP4, GIMAP5 +13 more | |
| Macrophages | Inflammasome Oxidative Stress Inflammatory | ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54 +33 more | View in SCUBA |
| Monocytes | GIMAP activation Housekeeping | FGD2, GIMAP1, GIMAP4, GIMAP6, GIMAP7, GIMAP8, IRF2, NAGK +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Survival Regulation Immune regulation | ACTR3, C11orf98, CISH, FARSA, GIMAP1, GIMAP4, GIMAP5, GIMAP7 +7 more |
About the gene
| Synonyms | FLJ23467 |
|---|---|
| Chromosome | 1: 151156649-151159749 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Immunity, Innate immunity |
Function
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression. Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex. Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.