PYHIN1 — Pyrin and HIN domain family member 1
PYHIN1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PYHIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane trafficking Housekeeping | BCL2, CLSTN1, GLB1, GTF2I, HPSE, HSDL2, LENG8, MBIP +19 more | View in SCUBA |
| CD8⁺ T cells | Effector-Memory CD8 T cell maturation | CD27, CD44, CMC1, CST7, CXCR3, DUSP2, EOMES, F2R +8 more | View in SCUBA |
| Gamma-delta T cells | Butyrophilin gd Activation TCR Signaling | ABI1, ADD3, ANXA6, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1 +16 more | |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACAP2, APBB1IP, ARHGAP25, ATM, CD247, CHD9, CLCN3, DDX17 +14 more | |
| Natural Killer cells | Innate Sensing NK Regulation Immune regulation | ADRB2, DTHD1, FCRL6, LFNG, LIMD2, PLEK, PRR5L, UBE2F +1 more | View in SCUBA |
About the gene
| Synonyms | IFIX, MGC23885 |
|---|---|
| Chromosome | 1: 158930796-158977059 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle |
Function
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.