SERTAD1 — SERTA domain containing 1

SERTAD1 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SERTAD1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate early response Stress	ABHD5, CEBPB, CITED2, FAM53C, GADD45A, GADD45B, HEXIM1, HSPA2 +9 more	View in SCUBA
CD4⁺ T cells	Pol II Transcription Regulation DNA/chromatin regulation	ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more	View in SCUBA
CD8⁺ T cells	Immediate Early Response Stress	ARRDC3, ATF3, CLK1, EIF4A2, EIF5, GADD45B, IER5, JUN +6 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DNAJB1, DUSP1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A +11 more	View in SCUBA
Fibroblasts	NF-κB Immediate Early Inflammatory	ATF3, DNAJA1, DUSP1, HLA-E, HSPA8, IRF1, MAFF, NFKBIA +4 more	View in SCUBA
Gamma-delta T cells	Heat Stress Apoptotic Stress	AMD1, DBF4, DNAJB9, DUSP2, IER5, NFKBIB, NINJ1, PHLDA1 +5 more
Glial cells	Integrated Stress Response Stress	ATF3, CCNL1, DNAJA1, DUSP1, HSPA8, HSPH1, KLF4, MAFF +2 more	View in SCUBA
Innate lymphoid cells	ILC3 Transcriptional Identity Differentiation	ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1 +12 more	View in SCUBA
Lymphatic endothelial	Integrated Stress Response Stress	ATF3, CSRNP1, DDIT3, DNAJA1, EIF4A2, HSP90AB1, PPP1R15A, RSRC2 +2 more	View in SCUBA
Macrophages	Lipid-Sensing Transcriptional Lipid metabolism	ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2 +29 more	View in SCUBA
Mucosal-associated invariant T cell	Integrated Stress Response Stress	ATF4, EIF4A3, EIF5, FAM53C, IFRD1, MARCKSL1, MKNK2, ODC1 +7 more
Natural Killer cells	ER Stress Response Stress	ARF4, CYCS, DNAJB6, EIF4A3, EIF5, GADD45B, HERPUD1, SAP18	View in SCUBA
Smooth muscle cells	Immediate Early Response Stress	ABHD5, ARC, ARL5B, BRD2, DDIT3, EGR3, GDF11, HEXIM1 +4 more	View in SCUBA

About the gene

Synonyms	SEI1, TRIP-Br1
Chromosome	19: 40421589-40425992
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	Transcription, Transcription regulation

Function

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.