PPP1R15A — Protein phosphatase 1 regulatory subunit 15A

PPP1R15A belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PPP1R15A's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	BTG2, CD69, CD83, DUSP1, EIF1, FOS, FOSB, JUN +7 more	View in SCUBA
CD4⁺ T cells	Immediate Early AP-1 TCR/AP1/NFKb pathway	BTG2, CD69, CDKN1A, DUSP1, EGR1, FOS, FOSB, IER2 +6 more	View in SCUBA
CD8⁺ T cells	Immediate Early Response Stress	ARRDC3, ATF3, CLK1, EIF4A2, EIF5, GADD45B, IER5, JUN +6 more	View in SCUBA
Endothelial	Heat Shock Response Stress	BAG3, DNAJA1, DNAJA4, HSPA8, HSPD1, HSPE1, HSPH1, IER5 +2 more	View in SCUBA
Fibroblasts	NF-κB Immediate Early Inflammatory	ATF3, DNAJA1, DUSP1, HLA-E, HSPA8, IRF1, MAFF, NFKBIA +4 more	View in SCUBA
Gamma-delta T cells	ER Proteotoxic Stress Stress	ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB +13 more
Goblet cells	Goblet Cell Differentiation Epithelial development	CLDN4, EIF1, ELF3, KLF3, KLF4, MIDN, RAB11FIP1, TOB1	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	Integrated Stress Response Stress	ATF3, CSRNP1, DDIT3, DNAJA1, EIF4A2, HSP90AB1, RSRC2, SERTAD1 +2 more	View in SCUBA
Macrophages	NF-κB Inflammatory Activation Inflammatory	ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3 +19 more	View in SCUBA
Monocytes	Immediate-Early Inflammatory Inflammatory	CXCL2, CXCL3, CXCL8, DUSP2, EGR1, EGR2, NFKBIA, NFKBIZ +3 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	BTG2, CCNL1, CD69, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1 +7 more
Natural Killer cells	Integrated Stress Response Stress	FAM43A, IER2, IER5, MARCKSL1, NFKBIA, NFKBIZ, PMAIP1, PPP1R15B +1 more	View in SCUBA
Neutrophils	NF-κB Activation Inflammatory	EHD1, GRAMD1A, NBN, NFKB2, NFKBIA, NFKBIZ, PLAUR, PLEK +6 more
Smooth muscle cells	NF-kB Stress Response Stress	BHLHE40, CCNL1, FADS3, HSP90AB1, IER3, MIDN, NFKBIZ, THBS1 +1 more	View in SCUBA

About the gene

Synonyms	GADD34
Chromosome	19: 48872212-48876059
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Predicted intracellular proteins
Biological process	Apoptosis, Stress response, Translation regulation

Function

Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux. Also acts a viral restriction factor by attenuating HIV-1 replication. Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation. (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'- UTR

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.