IER2 — Immediate early response 2

IER2 belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IER2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate Early NFkB BCR/AP1/NFKb pathway	ARL5B, CDKN1A, CSRNP1, DUSP2, EGR1, EGR3, NFKBIA, PPP1R15B +3 more	View in SCUBA
CD4⁺ T cells	Immediate Early AP-1 TCR/AP1/NFKb pathway	BTG2, CD69, CDKN1A, DUSP1, EGR1, FOS, FOSB, IER5 +6 more	View in SCUBA
CD8⁺ T cells	AP-1 Early Activation TCR Signaling	BTG2, CD69, EGR1, FOS, FOSB, JUNB, LEPROTL1, LITAF +5 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DNAJB1, DUSP1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A +11 more	View in SCUBA
Gamma-delta T cells	AP-1 Immediate Early Response Stress	BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more
Glial cells	Immediate Early Gene Response Activation	DNAJB1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B +3 more	View in SCUBA
Goblet cells	Immediate Early Gene chromatin regulation & transcription	BTG2, DUSP1, EGR1, FOS, FOSB, JUN, JUNB, JUND	View in SCUBA
Innate lymphoid cells	Dissociation Stress Response Stress	C12orf57, CA2, CALM2, EHD1, EIF4A2, MEPCE, NDRG1, NUDT4 +9 more	View in SCUBA
Lymphatic endothelial	AP-1 Immediate Early Inflammation	DUSP1, EGR1, FOS, FOSB, HES1, HSPA8, JUN, JUNB +7 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	AP-1 Inflammatory Activation Inflammatory	COQ7, DUSP1, FOS, JUN, JUNB, KCNE1, KLF6, NAIP +2 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more
Natural Killer cells	Integrated Stress Response Stress	FAM43A, IER5, MARCKSL1, NFKBIA, NFKBIZ, PMAIP1, PPP1R15A, PPP1R15B +1 more	View in SCUBA
Neutrophils	Immediate Early Response Stress	ADM, BTG2, DUSP1, EGR1, FOS, JUNB, ZFP36
Pericytes	Immediate Early Gene Stress	DNAJB1, EGR1, FOS, FOSB, HSPA1A, HSPA1B, JUN, JUNB +3 more	View in SCUBA
Smooth muscle cells	Immediate Early Response Stress	ATF3, BTG1, BTG2, CDKN1A, EGR1, FOS, GADD45B, HES1 +7 more	View in SCUBA

About the gene

Synonyms	ETR101
Chromosome	19: 13150411-13154911
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	DNA-binding

Function

DNA-binding protein that seems to act as a transcription factor. Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.