TIPARP — TCDD inducible poly(ADP-ribose) polymerase

TIPARP belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TIPARP's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Plasma cell secretory B cell maturation	AARSD1, ATP1B3, BCAS2, CHMP1B, DNAJB9, ELL2, ETV3, IDI1 +9 more	View in SCUBA
CD4⁺ T cells	NF-kB Feedback Response TCR/AP1/NFKb pathway	ADGRE5, ARL5B, ATF3, CSRNP1, NFKBIZ, PPP1R15B, RASGEF1B, TNFAIP3 +2 more	View in SCUBA
Endothelial	Endothelial Chemokine Response Chemotaxis	BMP2, CCL2, CEBPB, CEBPD, CNKSR3, CXCL1, CXCL2, CXCL3 +14 more	View in SCUBA
Fibroblasts	Proteotoxic Stress Survival Stress	ARL5B, BAG3, DNAJA4, ICAM1, PPIF, PPP1R15B, SLC25A25, TNFRSF10D	View in SCUBA
Gamma-delta T cells	Chromatin Epigenetic Regulation DNA/chromatin regulation	ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C +17 more
Innate lymphoid cells	NR4A Activation Response activation	ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1 +16 more	View in SCUBA
Lymphatic endothelial	AhR mRNA Regulation RNA processing & translation	CYP1B1, DHRS3, ESAM, HNRNPDL, HNRNPH1, LIF, SDC4, TPBG +3 more	View in SCUBA
Macrophages	Lipid-Sensing Transcriptional Lipid metabolism	ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2 +29 more	View in SCUBA
Monocytes	Integrated Stress Response Stress	CDKN1A, CSRNP1, EIF2AK3, HBEGF, KLF10, MAFF, PIM3	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Activation Inflammation	DUSP5, DUSP8, ELL2, GABARAPL1, IRF2BP2, MAFF, NAMPT, NFKB1 +8 more
Natural Killer cells	MAPK/AP-1 Signaling Inflammation	B3GNT7, BRAF, FAM177A1, FOSL2, GPBP1, PDE4B, PIK3R1, RALGAPA1 +4 more	View in SCUBA

About the gene

Synonyms	ARTD14, DDF1, DKFZP434J214, DKFZp686N0351, PARP-1, PARP-7, PARP7, pART14, RM1
Chromosome	3: 156673235-156706770
Predicted location	Intracellular
Essential gene	No
Protein class	Metabolic proteins, Predicted intracellular proteins
Molecular function	Glycosyltransferase, Nucleotidyltransferase, Transferase

Function

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins. Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.