VPS37B — VPS37B subunit of ESCRT-I

VPS37B belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

VPS37B's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Hypoxia/metabolic stress Stress	ALG13, ARL4A, C9orf72, HIP1R, PDE4B, SC5D, SLC2A3, TENT5C +2 more	View in SCUBA
CD4⁺ T cells	Immediate early activation TCR/AP1/NFKb pathway	ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2 +18 more	View in SCUBA
Endothelial	Glucocorticoid Response Endothelial cell development	APOLD1, DENND3, DPYSL2, JAM3, KLF11, KLF9, MFSD6, NDRG1 +8 more	View in SCUBA
Gamma-delta T cells	Late Activation Autophagy Immune regulation	BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1 +19 more
Innate lymphoid cells	Prostaglandin-AP1 Response Inflammation	ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2 +12 more	View in SCUBA
Mucosal-associated invariant T cell	Co-transcriptional Splicing RNA processing & translation	C9orf78, CCDC85C, CCNK, CDKN1B, DNTTIP2, EIF4B, ILF3, LAPTM5 +16 more
Natural Killer cells	MAPK/AP-1 Signaling Inflammation	B3GNT7, BRAF, FAM177A1, FOSL2, GPBP1, PDE4B, PIK3R1, RALGAPA1 +4 more	View in SCUBA
Neutrophils	Inflammatory Resolution Stress	ARL5B, ATG2A, ATP2B1, BTG1, CREM, DDIT4, FOSL2, GPR65 +4 more

About the gene

Synonyms	FLJ12750
Chromosome	12: 122865330-122896127
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	Protein transport, Transport

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.