INTS6 — Integrator complex subunit 6

INTS6 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

INTS6's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate early response Stress	ABHD5, CEBPB, CITED2, FAM53C, GADD45A, GADD45B, HEXIM1, HSPA2 +9 more	View in SCUBA
CD4⁺ T cells	Pol II Transcription Regulation DNA/chromatin regulation	ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more	View in SCUBA
Endothelial	Notch Arterial Identity Endothelial cell development	ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2 +14 more	View in SCUBA
Fibroblasts	Co-transcriptional RNA Processing Housekeeping	FUS, IFRD1, PCF11, PPP1R10, RSRP1, TSPYL2, YME1L1	View in SCUBA
Gamma-delta T cells	AP-1 Immediate Early Response Stress	BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more
Glial cells	Hypoxia mTOR Stress Stress	AMD1, CDKN2AIP, CITED2, DDIT4, HEXIM1, HSPA2, IFRD1, NEU1 +3 more	View in SCUBA
Innate lymphoid cells	mTOR Stress Response Stress	CEBPB, DDIT3, DDIT4, GLS, ID1, IFRD1, JMJD6, KLF4 +9 more	View in SCUBA
Lymphatic endothelial	DNA Damage Response DNA/chromatin regulation	BRD2, BTG2, CITED2, H2AX, HBEGF, HEXIM1, MAFB, NR4A1 +7 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more
Natural Killer cells	Transcription Elongation Control DNA regulation & transcription	C6orf62, FAM53C, FUS, HEXIM1, MAT2A, NABP1, PCF11, PPP1R10 +2 more	View in SCUBA
Smooth muscle cells	Immediate Early Response Stress	ABHD5, ARC, ARL5B, BRD2, DDIT3, EGR3, GDF11, HEXIM1 +4 more	View in SCUBA

About the gene

Synonyms	DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2
Chromosome	13: 51354077-51454264
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins

Function

Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause- release checkpoint. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.