HCFC1R1 — Host cell factor C1 regulator 1
HCFC1R1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HCFC1R1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ECM Homeostasis ECM remodeling | CAST, CAVIN3, FAM114A1, MXRA7, PPIC, SELENOW, TIMP2, TUBB | View in SCUBA |
| Gamma-delta T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23 +20 more | |
| Glial cells | TGF-beta ECM Remodeling ECM remodeling | GALNT2, ITGB8, LOXL3, PDGFA, RCAN1, S1PR3, SPRY1 | View in SCUBA |
| Macrophages | Oxidative Metabolic Program Mitochondrial & OxPhos | ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more | View in SCUBA |
| Pericytes | Myosin Phosphatase Regulation Cytoskeletal | CALM2, CRIP1, CRYAB, JAG1, LBH, MAP3K7CL, PHLDA2, PLAC9 +2 more | View in SCUBA |
| Smooth muscle cells | Oxidative Muscle Metabolism Mitochondrial & OxPhos | CAV2, COX7A1, CRIP2, FXYD1, LGR6, MFGE8, MGST3, NDUFB7 +2 more | View in SCUBA |
About the gene
| Synonyms | FLJ20568, HPIP |
|---|---|
| Chromosome | 16: 3022625-3024286 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.