SMAP2 — Small ArfGAP2

SMAP2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SMAP2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NFkB/MAPK activation BCR/AP1/NFKb pathway	BIRC3, CCDC107, CD72, CHI3L2, CLEC2B, DENND4A, LRRFIP1, MAP3K8 +7 more	View in SCUBA
CD4⁺ T cells	Ribosome biogenesis Housekeeping	APEX1, APRT, C1QBP, CCDC59, HNRNPA1, IMPDH2, LBH, LDHA +17 more	View in SCUBA
Gamma-delta T cells	TCR Inhibitory Signaling Exhaustion	AFF4, CBLB, CCNH, CCNT1, CHD2, CRYBG1, FYN, ISG20 +9 more
Innate lymphoid cells	ILC3 identity Differentiation	BHLHE40, BRD4, CASK, CITED2, GLUL, GNAS, HECA, IGFBP7 +19 more	View in SCUBA
Monocytes	Glucocorticoid Response Tissue adaptation	FKBP5, FMN1, MIS18BP1, NUDT16, SAP30, SPTLC2, SULT1A1, TSC22D3 +2 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Quiescence T cell maturation	AGO2, AUTS2, BCL6, BRD1, CSNK1D, DHCR7, FOXO1, GABPB1 +13 more
Neutrophils	Endosomal Vesicle Trafficking Vesicular traficking	FKBP5, FLOT2, IQGAP1, MYO1F, RGS18, RIPOR2, SORL1
Smooth muscle cells	Sparse Mitoribosomal Housekeeping Housekeeping	CEP63, CIB1, CTNNA1, ERGIC3, FBXO17, LEPROT, MRPL32, MRPL41 +6 more	View in SCUBA

About the gene

Synonyms	SMAP1L
Chromosome	1: 40344850-40423326
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	GTPase activation

Function

GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.