MRPL41 — Mitochondrial ribosomal protein L41
MRPL41 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MRPL41's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | OxPhos & proteasome Mitochondrial & OxPhos | CCDC167, CLTA, COX17, COX5A, DBI, FKBP1A, FMNL1, GALM +10 more | View in SCUBA |
| Goblet cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARPC5L, CALM1, EIF5A, LSM7, MRPL17, MRPL20, PFN1, PRELID1 +4 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, APOL3, ATP6V1E1, ECHS1, ERCC1, ETFB, GLRX3 +12 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 more | View in SCUBA |
| Smooth muscle cells | Sparse Mitoribosomal Housekeeping Housekeeping | CEP63, CIB1, CTNNA1, ERGIC3, FBXO17, LEPROT, MRPL32, MRPS7 +6 more | View in SCUBA |
About the gene
| Synonyms | BMRP, MRP-L27, MRPL27, PIG3, RPML27 |
|---|---|
| Chromosome | 9: 137551879-137552555 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Ribosomal proteins |
| Molecular function | Ribonucleoprotein, Ribosomal protein |
| Biological process | Apoptosis, Cell cycle |
Function
Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.