TWSG1 — Twisted gastrulation BMP signaling modulator 1
TWSG1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TWSG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Endothelial Activation Inflammation | ANXA6, CNIH1, COTL1, DEGS1, DHRS7, F2R, FKBP10, FSTL1 +8 more | View in SCUBA |
| Fibroblasts | Actin Cytoskeletal Organization Cytoskeletal | ACP1, AKR7A2, ARL3, CAPZB, DERL1, GDE1, LEPROTL1, LIMS1 +8 more | View in SCUBA |
| Smooth muscle cells | Generic maintenance transcripts Housekeeping | CHMP2A, EMP3, HMGN1, MRPL57, NCKAP1, PAIP2, PSMB2, SLC25A5 +5 more | View in SCUBA |
About the gene
| Synonyms | TSG |
|---|---|
| Chromosome | 18: 9334767-9402420 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Developmental protein |
Function
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.