UQCRC1 — Ubiquinol-cytochrome c reductase core protein 1
UQCRC1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UQCRC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mitochondrial Energy Metabolism Mitochondrial & OxPhos | ALDH1A1, ALDH3A2, CPS1, GALM, GCNT1, GPI, GSTM4, MTCH2 +2 more | View in SCUBA |
| Gamma-delta T cells | Cellular Homeostasis Housekeeping | ANAPC11, BANF1, CALM3, CBX3, CBX5, COMMD4, DPM2, DUT +21 more | |
| Goblet cells | Electron Transport Chain Mitochondrial & OxPhos | ATP5IF1, ATP5ME, COX5B, DCXR, NDUFA2, NDUFA3, NDUFB1, NDUFB10 +5 more | View in SCUBA |
| Innate lymphoid cells | Cellular Metabolic Maintenance Metabolism | ADIPOR1, APH1A, ARF5, BCAP31, CLIC1, CSNK2B, CYB5R3, DHPS +13 more | View in SCUBA |
| Macrophages | Mitochondrial Housekeeping Mitochondrial & OxPhos | BLOC1S2, BUD31, C14orf119, CCT5, CDC26, DGUOK, EIF2S1, GADD45GIP1 +11 more | View in SCUBA |
| Smooth muscle cells | Generic maintenance transcripts Housekeeping | CHMP2A, EMP3, HMGN1, MRPL57, NCKAP1, PAIP2, PSMB2, SLC25A5 +5 more | View in SCUBA |
About the gene
| Synonyms | D3S3191, QCR1, UQCR1 |
|---|---|
| Chromosome | 3: 48599002-48610976 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Biological process | Electron transport, Respiratory chain, Transport |
Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.