Actin Cytoskeletal Scaffold
Gene co-expression module in Smooth muscle cells
| Category | Cytoskeletal |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by actin-cytoskeletal and focal-adhesion scaffolding proteins characteristic of smooth muscle cells: PALLD (palladin), ACTN4 (alpha-actinin-4), NEXN (nexilin), PDLIM5 (ENH), MSN (moesin), LRRFIP1 (actin-binding FLI-I partner), ROCK2 (Rho-kinase, actomyosin regulator), FAT1 (cadherin controlling SMC actin/migration), plus nucleo-cytoskeletal linker LMNA and dynein adaptor PAFAH1B1 (LIS1). Calcium-handling partners of the contractile apparatus (ATP2B4 plasma-membrane Ca2+ ATPase, JPH2 junctophilin-2) and GNAI2 signaling link this scaffold to excitation-contraction coupling. A minor set of ubiquitous genes (YWHAZ, DDX5, EIF4G2, ATRX, NEMF, LYPLA1) reflects a broadly expressed housekeeping tail, consistent with moderate coherence and uniform detection (no subset enrichment, so not contamination). Within the neighborhood this module represents the structural/cytoskeletal scaffold arm rather than an inflammatory or stress program.
Genes
ACTN4, ATP2B4, ATRX, DDX5, DLGAP4, EIF4G2, FAT1, GNAI2, JAK1, JPH2, LMNA, LRRFIP1, LYPLA1, MSN, NEMF, NEXN, PAFAH1B1, PALLD, PDLIM5, ROCK2, WASF2, YWHAZ
Most correlated modules
- hnRNP & Proteasome · correlation 0.67
- BAG3-HSPB8 proteostasis · correlation 0.67
- STAT3 transcriptional program · correlation 0.66
- KLF6/ZNF24 regulators · correlation 0.65
- ER-Golgi Secretory · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.