SLCO3A1 — Solute carrier organic anion transporter family member 3A1
SLCO3A1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLCO3A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAM23, CTSW, EMP3, FKBP2, IFITM2, IGFBP3, KLRG1, LYAR +11 more | View in SCUBA |
| Enterocytes | Surface colonocyte transport Absorption | CA4, CD46, CITED1, CLCN1, DOCK4, GSN, HSPB1, ITM2C +4 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
| Smooth muscle cells | Vascular Tone Signaling Contractility | ADCY3, CPEB4, CYSTM1, DBI, EPAS1, EPS8, IER5L, NR2F2 +5 more | View in SCUBA |
About the gene
| Synonyms | OATP-D, OATP3A1, SLC21A11 |
|---|---|
| Chromosome | 15: 91853708-92172435 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Transport |
Function
Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner. The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.