MYO1C — Myosin IC
MYO1C belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MYO1C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitophagy Stress Response Stress | C1QTNF12, CDA, CPNE2, FAM219A, FCN3, GSDMC, IGFBP3, INSR +7 more | View in SCUBA |
| Smooth muscle cells | Post-translational regulators Housekeeping | ANXA11, BAG1, BANF1, CALM3, CAMTA1, ERH, HMGN3, NENF +6 more | View in SCUBA |
About the gene
| Synonyms | MyoIC, myr2, NMI |
|---|---|
| Chromosome | 17: 1464186-1492686 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Function
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.