SPTLC2 — Serine palmitoyltransferase long chain base subunit 2
SPTLC2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPTLC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia Response Stress | CNTNAP3B, ENOSF1, FBN1, FKBP5, FOXP2, HIF3A, HMCN1, KAT2B +11 more | View in SCUBA |
| Monocytes | Glucocorticoid Response Tissue adaptation | FKBP5, FMN1, MIS18BP1, NUDT16, SAP30, SMAP2, SULT1A1, TSC22D3 +2 more | View in SCUBA |
| Neutrophils | JAK-MAPK Signaling Inflammatory | CELF2, ENTPD1, GIT2, JAK2, MAPK1, MBNL1, SLMAP, TLE4 +1 more |
About the gene
| Synonyms | hLCB2a, KIAA0526, LCB2, LCB2A |
|---|---|
| Chromosome | 14: 77505997-77616637 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Lipid metabolism, Sphingolipid metabolism |
Function
Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Crucial for adipogenesis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.