SF1 — Splicing factor 1
SF1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Modification DNA/chromatin regulation | AKAP13, CREBRF, EPC1, GCC2, GPBP1, JMJD1C, KMT2E, OFD1 +6 more | View in SCUBA |
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | AP3M2, ATP1B3, CREM, CRYBG1, DCTN6, EZR, FAM177A1, FTH1 +19 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing Processing RNA processing & translation | ARHGEF1, BECN1, CCNI, DENND4B, EID1, HNRNPA0, HNRNPDL, KLHDC4 +18 more | |
| Macrophages | Pre-mRNA Splicing Housekeeping | BCLAF1, CSNK1A1, DDX3X, DDX5, EWSR1, FUS, HNRNPH1, HNRNPH3 +11 more | View in SCUBA |
| Mucosal-associated invariant T cell | Housekeeping Translation Housekeeping | ARHGDIA, ARHGEF1, CCNI, DAZAP2, EEF2, HLA-A, HLA-B, HNRNPA1 +4 more |
About the gene
| Synonyms | ZCCHC25, ZFM1, ZNF162 |
|---|---|
| Chromosome | 11: 64764606-64778786 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Repressor, RNA-binding |
| Biological process | mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Function
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.