SRRM1 — Serine and arginine repetitive matrix 1
SRRM1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SRRM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA splicing RNA processing | ANAPC5, C11orf58, C1orf43, DDX46, DNAJC7, HSPA4, LSM14A, LUC7L3 +8 more | View in SCUBA |
| CD8⁺ T cells | Nuclear RNA Splicing RNA processing & translation | CBX3, DNAJC8, HNRNPA3, HNRNPD, HNRNPR, MAZ, PGP, PPIG +5 more | View in SCUBA |
| Gamma-delta T cells | Hypoxia Stress Response Stress | ARIH2, BNIP2, C9orf78, CHD4, FBXO7, HIF1A, HNRNPH1, JADE1 +16 more | |
| Innate lymphoid cells | Splicing & Transcription RNA processing & translation | ACTR2, BDP1, CDC5L, CYLD, DHX36, FXR1, GPATCH2, MTPN +12 more | View in SCUBA |
| Macrophages | RNA Processing & Repair Housekeeping | BRD7, CCDC59, CCT4, CCT6A, CNDP2, EIF3J, EIF5B, EMC4 +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | Housekeeping Translation Housekeeping | ARHGDIA, ARHGEF1, CCNI, DAZAP2, EEF2, HLA-A, HLA-B, HNRNPA1 +4 more |
About the gene
| Synonyms | MGC39488, POP101, SRM160 |
|---|---|
| Chromosome | 1: 24631716-24673281 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | DNA-binding, RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence- specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.