RAB29 — RAB29, member RAS oncogene family
RAB29 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB29's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | ARID5A, CD52, CD74, CD79A, CTSS, CYBA, HLA-DPA1, HLA-DPB1 +9 more | View in SCUBA |
| Gamma-delta T cells | Coinhibitory Checkpoint Exhaustion | BTN3A2, CDC25B, CDC42EP3, DDTL, FAM117A, FLOT2, GBP5, GGPS1 +12 more | |
| Mucosal-associated invariant T cell | Lymphocyte Trafficking migration & adhesion | AASDHPPT, ANXA2, ARL14EP, ATP2A3, BIN1, BTN3A2, DGKZ, OSTC +8 more |
About the gene
| Synonyms | RAB7L, RAB7L1 |
|---|---|
| Chromosome | 1: 205767986-205775482 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Differentiation, Protein transport, Transport |
Function
The small GTPases Rab are key regulators in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity. Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2. Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.typhi) epithelial cell infection.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.