Inflammatory Angiogenesis
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
NFATC1 is a transcription factor activated downstream of VEGFR2 and calcium signaling, driving angiogenic gene expression. PIM3 is a pro-survival serine/threonine kinase upregulated by cytokines and growth factors in endothelial cells. RALGDS is a RAS effector linking RAS to RAL GTPases in angiogenic signaling. MYC drives proliferation downstream of VEGF. KLF6 is a stress- and injury-responsive KLF family member. RGS16 modulates GPCR/chemokine signaling. PHLDA1 is induced by growth factors and stress. RORA is a nuclear receptor with anti-inflammatory and circadian roles. SSH1 activates cofilin for cytoskeletal remodeling during migration. SLC38A2 supports amino acid uptake for proliferating cells. The module is significantly upregulated in both UC and CD inflammation, consistent with inflammatory angiogenesis. As a neighbor to M63, both modules represent inflammation-activated programs, with M111 more focused on growth factor/angiogenic signaling.
Genes
FAM241A, FAM43A, KLF6, MYC, NFATC1, PHLDA1, PIM3, PLEKHO2, RALGDS, RGS16, RHOU, RORA, SLC38A2, SSH1, TMEM70, TPT1
Most correlated modules
- Endothelial Chemokine Response · correlation 0.81
- NF-κB Activation · correlation 0.80
- NF-κB Early Response · correlation 0.77
- Integrated Stress Response · correlation 0.74
- NF-κB Endothelial Activation · correlation 0.73
- Inflammatory EC Activation · correlation 0.70
- Heat Shock Response · correlation 0.70
- Endothelial Cell Migration · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.