Mitochondrial Oxidative Stress
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
This module contains PARK7/DJ-1 (oxidative stress sensor, mitochondrial quality control), PRDX5 (mitochondrial/peroxisomal peroxiredoxin, antioxidant), PRELID1 (mitochondrial lipid transfer, cardiolipin metabolism), ECHS1 (mitochondrial short-chain enoyl-CoA hydratase, fatty acid oxidation), and TIMM-pathway neighbor TRAPPC1. ECSCR is an endothelial-specific gene involved in chemotaxis/apoptosis. NEDD8 (neddylation/protein degradation), PSME2 (proteasome activator), EIF5A (translation), AP2M1 (endocytosis), AGTRAP (angiotensin receptor-associated). The module is upregulated in IBD inflammation and downregulated in remission. The combination of PARK7, PRDX5, ECHS1, and PRELID1 points to mitochondrial oxidative stress response, with ECSCR providing endothelial specificity. As a neighbor of M64 and M104, this module extends the mitochondrial stress theme with an antioxidant/quality control emphasis.
Genes
AGTRAP, AP2M1, ECHS1, ECSCR, EDF1, EIF5A, NEDD8, PARK7, PHPT1, PRDX5, PRELID1, PSME2, S100A16, TRAPPC1
Most correlated modules
- Respiratory Chain Complex · correlation 0.91
- p53 Stress Response · correlation 0.90
- Redox Stress Response · correlation 0.90
- Housekeeping Metabolic · correlation 0.85
- ER-Golgi Trafficking · correlation 0.84
- Mitochondrial OxPhos · correlation 0.83
- Inflammatory Stress Response · correlation 0.82
- Oxidative Phosphorylation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.