Oxidative Phosphorylation
Gene co-expression module in Endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes include ATP5MC2, ATP5F1D, ATP5PO (ATP synthase subunits), UQCRB (ubiquinol-cytochrome c reductase, Complex III), COX7C (cytochrome c oxidase, Complex IV), HIGD2A (hypoxia-inducible domain, mitochondrial), MRPL14 (mitochondrial ribosomal protein), SLC25A6 (mitochondrial ADP/ATP translocator), PHB2 (prohibitin 2, mitochondrial inner membrane). These are canonical oxidative phosphorylation and mitochondrial components. ERP29 (ER protein), YBX1 (RNA-binding), LSM2 (RNA splicing) are peripheral. The module has high mean expression and pct positive, consistent with housekeeping mitochondrial function. Mild inflammation upregulation may reflect metabolic demand. The OxPhos signature is dominant.
Genes
ATP5F1D, ATP5MC2, ATP5PO, COX7C, ERP29, HIGD2A, HINT1, IMPDH2, LSM2, LY96, MRPL14, PHB2, SLC25A6, TBCA, TMEM14C, TSHZ2, UQCRB, UXT, YBX1
Most correlated modules
- Translation Elongation · correlation 0.87
- Angiogenic Metabolic Adaptation · correlation 0.87
- p53 Stress Response · correlation 0.85
- Redox Stress Response · correlation 0.83
- Respiratory Chain Complex · correlation 0.83
- Mitochondrial Oxidative Stress · correlation 0.82
- Inflammatory Stress Response · correlation 0.81
- Lysosomal Autophagy Program · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.