Redox Stress Response
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes TXN (thioredoxin, major cellular redox buffer), APEX1 (AP endonuclease 1, DNA base excision repair and redox regulation of transcription factors), and PARK7-neighbor TIMM13 (mitochondrial intermembrane space import) anchor a redox/stress response. NME1 (nucleoside diphosphate kinase, proliferation/metastasis), REXO2 (RNA exonuclease), MRPL12/MRPS6 (mitoribosome subunits), ATP5F1E/ATP5MC1/UQCRH (OxPhos), EIF4EBP1 (mTOR-regulated translation repressor, stress response), CDC42EP5 (Cdc42 effector, cytoskeletal), MAGED1 (apoptosis regulator), MCFD2 (LMAN1 cargo receptor, ER-Golgi), TMEM123 (membrane protein). The co-expression of TXN, APEX1, and EIF4EBP1 with mitoribosome and OxPhos genes suggests a coupled redox-stress and mitochondrial translation program. As a neighbor of M64 (OxPhos) and M48 (cytoskeletal), this module bridges mitochondrial function with cellular redox homeostasis. Upregulated in IBD inflammation, consistent with oxidative stress in inflamed endothelium.
Genes
APEX1, ATP5F1E, ATP5MC1, CDC42EP5, EIF4EBP1, EPS8L1, MAGED1, MCFD2, MRPL12, MRPS6, NME1, REXO2, TIMM13, TMEM123, TXN, UQCRH
Most correlated modules
- p53 Stress Response · correlation 0.94
- Respiratory Chain Complex · correlation 0.90
- Mitochondrial Oxidative Stress · correlation 0.90
- Inflammatory EC Activation · correlation 0.85
- Housekeeping Metabolic · correlation 0.85
- Endothelial Cell Migration · correlation 0.83
- Oxidative Phosphorylation · correlation 0.83
- Actin Cytoskeletal Remodeling · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.