Respiratory Chain Complex
Gene co-expression module in Endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Highly coherent module dominated by mitochondrial respiratory chain subunits: NDUFB11, NDUFS8, NDUFV2 (Complex I), UQCR10 (Complex III), ATP5MG (Complex V). CHCHD2 is a mitochondrial intermembrane space protein involved in Complex I/IV assembly and mitochondrial cristae organization. MTCH2 is a mitochondrial outer membrane carrier. HSBP1 modulates small heat shock proteins, potentially linked to mitochondrial proteostasis. SNRPD2 is a peripheral spliceosome member. Upregulated in IBD inflammation and strongly reversed in remission, consistent with increased oxidative phosphorylation demand in inflamed endothelium. Tight neighbor to M3 which also contains OxPhos genes.
Genes
ATP5MG, CHCHD2, HSBP1, MTCH2, NDUFB11, NDUFS8, NDUFV2, SNRPD2, UQCR10
Most correlated modules
- ER-Golgi Trafficking · correlation 0.92
- Glycolysis Activation · correlation 0.91
- ER Protein Processing · correlation 0.91
- Mitochondrial Oxidative Stress · correlation 0.91
- Redox Stress Response · correlation 0.90
- Mitochondrial OxPhos · correlation 0.90
- Housekeeping Metabolic · correlation 0.89
- p53 Stress Response · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.