EC Quiescence Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes PTPRB (vascular-specific receptor tyrosine phosphatase, marker of quiescent ECs) and PTPRM (receptor phosphatase) are top-ranked. ABCC4 (ABC transporter expressed in ECs), TMTC1, MSI2 (RNA-binding protein), SLC16A14 (monocarboxylate transporter), IFNAR2 (interferon receptor), ENPP4 (ectonucleotidase). The module is significantly downregulated in inflammation and restored in remission, consistent with a quiescent EC homeostatic identity program. PTPRB in particular is a canonical marker of resting endothelium.
Genes
ABCC4, ARHGAP5, C1orf115, ENPP4, FAM107A, GIT2, IFNAR2, LRRFIP1, MSI2, NEK7, PTPRB, PTPRM, SHE, SLC16A14, STON1, TMTC1, TTC28
Most correlated modules
- Cytoskeletal Scaffolding · correlation 0.90
- Arterial EC Identity · correlation 0.88
- Vascular EC Identity · correlation 0.87
- Vascular Homeostasis · correlation 0.86
- EC Barrier Integrity · correlation 0.84
- Hypoxia-IFN Endothelial · correlation 0.84
- Caveolae-mediated Transcytosis · correlation 0.84
- EC Inflammatory Activation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.