TGF-beta ECM Remodeling
Gene co-expression module in Endothelial
| Category | ECM remodeling |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes TIMP2 (MMP inhibitor, ECM homeostasis), TGFB1 (TGF-beta 1, master regulator of ECM remodeling and fibrosis), EFEMP2 (fibulin-4, elastic fiber ECM component), TNXB (tenascin-X, ECM glycoprotein), SDC3 (syndecan-3, heparan sulfate proteoglycan), ADAM10 (metalloprotease/sheddase), and WWTR1 (TAZ, mechanosensing transcriptional coactivator) collectively define a TGF-beta-driven ECM remodeling program in endothelial cells. TIE1 and APLP2 support vascular homeostasis context. HIPK2 is a known regulator of TGF-beta signaling. The module is broadly expressed (40% pct positive) and shows modest disease associations, consistent with a constitutive but regulated ECM program. Neighbor relationship with M115 (quiescent EC identity) supports a homeostatic vascular program.
Genes
ADAM10, APLP2, CCNDBP1, CYB5R3, DHRS3, EFEMP2, GNAS, HIPK2, MGST2, REEP3, SDC3, TGFB1, TIE1, TIMP2, TNS1, TNXB, TSPAN14, WWTR1, YES1
Most correlated modules
- EC Cytoskeletal Scaffold · correlation 0.71
- Arterial EC Identity · correlation 0.56
- YAP Mechanotransduction · correlation 0.54
- Inflammatory Angiogenesis · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.