TIMP2 — TIMP metallopeptidase inhibitor 2
TIMP2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TIMP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | TGF-beta ECM Remodeling ECM remodeling | ADAM10, APLP2, CCNDBP1, CYB5R3, DHRS3, EFEMP2, GNAS, HIPK2 +10 more | View in SCUBA |
| Fibroblasts | ECM Homeostasis ECM remodeling | CAST, CAVIN3, FAM114A1, HCFC1R1, MXRA7, PPIC, SELENOW, TUBB | View in SCUBA |
| Glial cells | ECM Homeostatic Regulation ECM remodeling | BPTF, KCTD12, MAPRE2, OAF, SASH1, ST3GAL6, TTC3 | View in SCUBA |
| Lymphatic endothelial | Caveolae Cytoskeletal Cytoskeletal | CALM1, CAVIN1, CRIP2, CTSZ, DYNLL1, EPHX1, GSTK1, HOXD8 +7 more | View in SCUBA |
| Macrophages | ER-Lysosome Trafficking Vesicular traficking | BPNT2, CALU, CLPTM1L, CTSB, DHRS7, EMC10, GBA1, GNS +21 more | View in SCUBA |
| Smooth muscle cells | Matrisome Regulators ECM remodeling | ITM2C, LPP, LUM, NBL1, PMP22, S100A13, TCEAL4, TMEM176B +1 more | View in SCUBA |
About the gene
| Synonyms | CSC-21K |
|---|---|
| Chromosome | 17: 78852977-78925387 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor |
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.