TCEA3 — Transcription elongation factor A3
TCEA3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TCEA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1 +21 more | View in SCUBA |
| Endothelial | Macrophage Contamination Cell contamination | CCDC68, CLEC7A, CORO2A, CPVL, DIXDC1, DOCK11, LPCAT4, PTGS1 +3 more | View in SCUBA |
| Enterocytes | Mature enterocyte transport Absorption | ABCG8, ANO6, ANXA13, KAZN, PIK3C2G, RASGEF1B, SLC16A10, TLN2 +1 more | View in SCUBA |
| Goblet cells | ER Chaperone Glycosylation Protein processing & ER | ANG, ATP6V1G1, CD63, FKBP2, NANS, OST4, PPIC, RABAC1 +4 more | View in SCUBA |
About the gene
| Synonyms | TFIIS.H |
|---|---|
| Chromosome | 1: 23380909-23424748 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.