MAGED1 — MAGE family member D1
MAGED1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAGED1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Redox Stress Response Stress | APEX1, ATP5F1E, ATP5MC1, CDC42EP5, EIF4EBP1, EPS8L1, MCFD2, MRPL12 +7 more | View in SCUBA |
| Lymphatic endothelial | Lymphangiogenesis ECM endothelial development | ARHGAP18, CEP68, CFI, DIPK2B, EGFL7, ELK3, ELN, FLT4 +10 more | View in SCUBA |
About the gene
| Synonyms | DLXIN-1, NRAGE |
|---|---|
| Chromosome | X: 51803007-51902354 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | Tumor antigen |
| Biological process | Biological rhythms, Ubl conjugation pathway |
Function
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl- conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.