MCFD2 — Multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
MCFD2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MCFD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Redox Stress Response Stress | APEX1, ATP5F1E, ATP5MC1, CDC42EP5, EIF4EBP1, EPS8L1, MAGED1, MRPL12 +7 more | View in SCUBA |
| Lymphatic endothelial | Integrin Focal Adhesion migration & adhesion | APLP2, ATP5F1A, ATP5PB, DEK, ITGB1, LIMS1, NPC2, NUCKS1 +4 more | View in SCUBA |
| Macrophages | Autophagy Lysosomal Regulation Lysosomal & pahgocytosis | ADIPOR1, ARL8A, ATOSB, BCL10, BROX, CCR1, CEBPB, CHMP2B +22 more | View in SCUBA |
About the gene
| Synonyms | F5F8D, LMAN1IP, SDNSF |
|---|---|
| Chromosome | 2: 46901870-46941855 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | ER-Golgi transport, Protein transport, Transport |
Function
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.