TPBG — Trophoblast glycoprotein
TPBG belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TPBG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, DSE, ERN1, GPR65, IFI44 +12 more | View in SCUBA |
| Endothelial | Arterial EC Identity Endothelial cell development | ADAM23, AGPAT2, CLDN5, ECHDC2, GOLGA8B, HHEX, LY6E, NDN +1 more | View in SCUBA |
| Fibroblasts | Metabolic Homeostasis Housekeeping | ADH5, ALDH2, ATP2B1, ISCU, NBL1, NLGN4X, PGM1, PKIG +4 more | View in SCUBA |
| Lymphatic endothelial | AhR mRNA Regulation RNA processing & translation | CYP1B1, DHRS3, ESAM, HNRNPDL, HNRNPH1, LIF, SDC4, TIPARP +3 more | View in SCUBA |
About the gene
| Synonyms | 5T4, 5T4-AG |
|---|---|
| Chromosome | 6: 82363206-82367420 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.