SMAD3 — SMAD family member 3
SMAD3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMAD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | TGF-beta/differentiation Intercellular communication | CDC42SE1, CEMIP2, ENC1, KLF3, LYST, SLC12A6, ST3GAL1, TSPAN3 | View in SCUBA |
| Enterocytes | Junctional Hippo/TGF-beta signaling Migration & adhesion | AFDN, BACH1, CCNL1, DAPK2, DST, PELI2, UACA, WWC1 | View in SCUBA |
| Gamma-delta T cells | TCR-Cytokine Signaling TCR Signaling | ARHGAP26, CACNA2D2, CCDC88C, LPGAT1, LY75, MED15, NBPF14, NBPF19 +10 more |
About the gene
| Synonyms | HsT17436, JV15-2, MADH3 |
|---|---|
| Chromosome | 15: 67063763-67195173 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.