NF-κB Immediate Early
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
This module is dominated by canonical immediate early response / NF-κB target genes: NFKBIA and NFKBIZ (IκB proteins, primary NF-κB feedback inhibitors), ATF3 (stress-induced ATF/CREB TF, immediate early), MAFF (small Maf, stress-responsive bZIP), SOCS3 (JAK-STAT feedback inhibitor, cytokine-induced), DUSP1 (MAPK phosphatase, immediate early), IRF1 (interferon/NF-κB target), PPP1R15A (GADD34, ISR/stress), ZFP36L1 (mRNA destabilizer, immediate early), HLA-E (MHC-I, inflammatory), DNAJA1 and HSPA8 (chaperones co-induced with stress). The pattern—high expression, broad detection, increased in both UC and CD inflammation—is the hallmark of the canonical NF-κB/immediate early inflammatory gene program in fibroblasts.
Genes
ATF3, DNAJA1, DUSP1, HLA-E, HSPA8, IRF1, MAFF, NFKBIA, NFKBIZ, PPP1R15A, SERTAD1, SOCS3, ZFP36L1
Most correlated modules
- Fibroblast Quiescence · correlation 0.92
- Heat Shock Response · correlation 0.91
- Proteotoxic Stress Survival · correlation 0.89
- Integrated Stress Response · correlation 0.84
- Type I Interferon · correlation 0.83
- NF-κB Epigenetic Reprogramming · correlation 0.82
- Cytokine Inflammatory Response · correlation 0.80
- Unfolded Protein Response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.