NEU1 — Neuraminidase 1

NEU1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NEU1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	ATF4 Stress Response Stress	ATF4, BRD2, CCNYL1, ERO1B, FUS, GLA, HMGCS1, INSIG1 +3 more	View in SCUBA
CD4⁺ T cells	Cytotoxic Effector CD4 Cytotoxicity	ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2 +13 more	View in SCUBA
CD8⁺ T cells	Immediate Early Response Stress	ARRDC3, ATF3, CLK1, EIF4A2, EIF5, GADD45B, IER5, JUN +6 more	View in SCUBA
Fibroblasts	Type I Interferon Inflammatory	ABHD5, HELZ2, ICAM4, IQCN, IRF7, IRF8, IRF9, LACTB +2 more	View in SCUBA
Gamma-delta T cells	Stress Epigenetic Silencing DNA/chromatin regulation	ALKBH5, ANKHD1, EPC2, FAM53C, MXD1, OTUD4, PHF1, PNO1 +8 more
Glial cells	Hypoxia mTOR Stress Stress	AMD1, CDKN2AIP, CITED2, DDIT4, HEXIM1, HSPA2, IFRD1, INTS6 +3 more	View in SCUBA
Innate lymphoid cells	ILC3 Transcriptional Identity Differentiation	ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1 +12 more	View in SCUBA
Mucosal-associated invariant T cell	Splicing Regulation RNA processing & translation	AREG, ARHGAP9, AZIN1, CCNH, CLK1, DDX24, DNAJB6, IL23R +9 more

About the gene

Synonyms	NEU
Chromosome	6: 31857659-31862905
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Molecular function	Glycosidase, Hydrolase
Biological process	Carbohydrate metabolism, Lipid degradation, Lipid metabolism

Function

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.