PKDCC — Protein kinase domain containing, cytoplasmic
PKDCC belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PKDCC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | CYGB+ Quiescent Fibroblast Housekeeping | CCND1, CYGB, FARP1, FGFR4, FXYD5, NCAM1, NEGR1, NOVA1 +5 more | View in SCUBA |
| Goblet cells | Colonocyte Metabolic Defense Mitochondrial & OxPhos | ACAA2, CAT, CRYBG1, GLIPR2, MLXIP, SAMD5, SEMA6A, ZFHX3 | View in SCUBA |
| Innate lymphoid cells | IFN-gamma Response Inflammation | APOL6, B3GALT5, DST, ELK3, GBP2, GBP4, GBP5, GOLGA8A +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Heat Shock Response Stress | AHSA1, BAG3, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4 +13 more |
About the gene
| Synonyms | SgK493, Vlk |
|---|---|
| Chromosome | 2: 42048021-42058517 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins |
| Molecular function | Developmental protein, Kinase, Transferase, Tyrosine-protein kinase |
| Biological process | Differentiation, Osteogenesis, Protein transport, Transport |
Function
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.