SNX10 — Sorting nexin 10
SNX10 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNX10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory ECM Remodeling ECM remodeling | ABRACL, ADAMTS2, CD82, CHI3L1, COTL1, GGCT, LXN, MT2A +5 more | View in SCUBA |
| Innate lymphoid cells | Actin Cytoskeleton Dynamics Cytoskeleton & motility | ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, CXXC5, FAM136A, FERMT3 +26 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9 +21 more | View in SCUBA |
About the gene
| Chromosome | 7: 26291862-26374383 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cilium biogenesis/degradation, Protein transport, Transport |
Function
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.